Get this course

Acute Toxicity

Nix the Six: Strategies for Implementing a Non-animal Acute Six-Pack


Description

Welcome to the NURA course Nix the Six: Strategies for Implementing a Non-animal Acute Six-Pack.


The acute toxicity "six-pack" is a collection of animal tests used to evaluate acute systemic toxicity by three routes of exposure, skin and eye irritation/corrosion, and skin sensitization. This course covers ways to replace the use of animals in the "six-pack" with more effective, human-based methods.


Speakers:

Jessica Ponder, PhD, (formerly) Physicians Committee for Responsible Medicine, Moderator

Kristie Sullivan, MPH (formerly) Physicians Committee for Responsible Medicine, Moderator

Raja Settivari, BVSc AH, PhD, DABT Corteva AgriScience

Kamel Mansouri, PhD NICEATM

Michael Lowit, PhD US EPA

Tara Flint, MA, US EPA

Mark Cronin, PhD, Liverpool John Moores University

Silvia Casati, PhD, European Commission Joint Research Centre

Hans Raabe, MS, Institute for In Vitro Sciences

Joseph Henriquez, PhD, Corteva AgriSciences

Joanna Matheson, PhD, Consumer Product Safety Commission

Amy J. Clippinger, PhD PETA Science Consortium International e.V. (panelist)

Dania Movia, PhD, Trinity College Dublin

Douglas Wolf, DVM, PhD Syngenta

Amy Blankinship, US EPA

Steve Edwards, RTI International

Ramya Rajagopal, PhD, DABT Unilever

Nicole Kleinstreuer, PhD, NICEATM


The videos in this course are available with English and Spanish subtitles. To access these, select the "Settings" (gear) icon within the video.

Content
  • Section 1 Introduction: Oral and Dermal Toxicity
  • 1.1 GHS Additivity for Pesticide Formulations
  • 1.2 Application of CATMoS to Ecological Risk assessment
  • 1.3 EPA Evaluation of NAMs for Acute Oral Toxicity
  • 1.4 EPA’s Acute Dermal Waiver Guidance
  • Roundtable 1: What is Still Needed to Predict Acute Oral Toxicity?
  • Section 2 Introduction: Dermal Sensitization
  • 2.1 In Silico Methods to Predict Skin Sensitization
  • 2.2 Defines Approach for Skin Sensitization
  • 2.3 Experience with SENS-IS
  • Roundtable 2: Complete Replacement for In Vivo Dermal Sensitization
  • Section 3 Introduction: Skin and Eye Irritation
  • 3.1 In Vitro Methods for Skin and Eye Irritation
  • 3.2 Identifying Irritants in Formulations
  • 3.3 Regulatory Assessment of Irritants
  • Roundtable 3: Establishing Reg. Confidence in NAMs for Mixtures and Formulations
  • Section 4 Introduction: Inhalation Toxicity
  • 4.1 In Vitro Assays for Acute Inhalation
  • 4.2 Respiratory Tools and Assays for Regulatory Toxicology
  • 4.3 Developing Integrated NAMs for Acute Respiratory Toxicology
  • Roundtable 4: Fast-Tracking Development of NAMs for Acute Inhalation
  • Section 5 Introduction: Opportunities and Outlook
  • 5.1 Guidance for Waiving or Bridging of Mammalian Acute Toxicity Tests
  • 5.2 Computational Methods for Leveraging Adverse Outcome Pathway Information
  • 5.3 Developing a Respiratory Sensitization IATA
  • 5.4 Nix the Six! How Close Are We?
  • Roundtable 5: Applying Experiences Across Endpoints
  • Course Survey
Completion rules
  • All units must be completed
  • Leads to a certificate with a duration: Forever
Back