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Computational Toxicology → in silico

NAMs to Address Population Variability and Susceptibility


Description

Welcome to the NURA course NAMs to Address Population Variability and Susceptibility!


The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods

The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods(NICEATM) co-organized a symposium webinar 

on October 26-27, 2022 on using new approach methodologies (NAMs) to address variability and susceptibility across populations. The symposium goals were to identify opportunities for NAMs to provide relevant information on population variability and susceptibility to environmental chemicals; and identify information needs for population variability and susceptibility where NAMs could be designed or improved to fill that need. In advance of the workshop, this webinar series was convened to highlight NAMs that incorporate variability and susceptibility into the evaluation of chemical safety.

  


Speakers:

Nicolas Gaudenzio, Ph.D., Genoskin

Gertrude-Emilia Costin, Ph.D., MBA, ATS, ERT, IIVS

Passley Hargrove-Grimes, Ph.D., US NIH

Arum Han, PhD, Texas A&M University

Shaun D. McCullough, PhD, (formerly) US EPA

Chirag J. Patel, PhD, Harvard Medical School


Moderators:

Helena Hogberg-Durdock, Ph.D., NICEATM

Kim To, Ph.D., (formerly) Inotiv

Oluwakemi Oyetade, MS, Inotiv


This course was recorded in October 2022. Credentials and affiliations for speakers and presenters may have changed since the recording.


The videos in this course are available with English and Spanish subtitles. To access these, select the "Settings" (gear) icon within the video.

Content
  • Course Intro: NAMs to Address Population Variability and Susceptibility
  • Section 1: NAMs to Address Population Variability and Susceptibility
  • Section 1 Intro: NAMs to Address Population Variability and Susceptibility
  • 1.1 Height-dimensional profiling of immune response using human skin
  • 1.2 Pre-clinical skin tone modulation using reconstructed tissue models
  • Section 1 Q&A
  • Section 2: Clinical Trials on Chips to Tackle Rate Diseases
  • Section 2 Intro: Clinical Trials on Chips to Tackle Rare Diseases
  • 2.1 Tissue Chips for Precision Medicine Applications
  • 2.2 Feto-Maternal Interface Tissue Chip Models for Preterm Birth Research
  • Section 2 Q&A
  • Section 3: Chemical Exposure and Susceptible Populations
  • Section 3 Intro: Chemical Exposure and Susceptible Populations 
  • 3.1 Impacts of variability on in vitro models for inhaled chemical safety
  • 3.2 Data science approaches to prioritize the exposomic determinants of health
  • Section 3 Q&A
  • Course Survey, PopVars
Completion rules
  • All units must be completed
  • Leads to a certificate with a duration: Forever
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