Get this course

Evaluating Toxicological Information Using Modern Science


Description

Welcome to the NURA course Evaluating Toxicological Information Using Modern Science.


This course covers the regulatory landscape regarding the reduction of animal use, NAM use for the assessment of acute systemic toxicity, demonstrations of computational approaches, and in vitro approaches for skin and eye assessment.


Speakers:

Monique Perron, PhD, US Environmental Protection Agency

Kristie Sullivan, MPH, (formerly) Physicians Committee for Responsible Medicine

Paul Hinderliter, PhD, DABT, Syngenta Crop Protection

Michelle Embry, PhD, Health and Environmental Sciences Institute

Kamel Mansouri , PhD, (formerly) Integrated Laboratory Systems, Inc.

Thomas Luechtefeld, PhD, Insilica

Antony Williams, PhD, US Environmental Protection Agency

Barbara Wetmore, PhD, US Environmental Protection Agency

Salil Pendse, MS, Scitovation

Alexandra Maertens, PhD, Consortium for Environmental Risk Management

Sricharan Bandhakavi, PhD, Edelweiss Connection

Raja Settivari, AH, PhD, DABT, Corteva

Holger Behrsing, PhD, Institute for In Vitro Sciences, Inc.

Pooja Desai, PhD, Institute for In Vitro Sciences, Inc

Nathan Wilt, Institute for In Vitro Sciences, Inc.

Tinashe Ruwona, PhD, DABT, Institute for In Vitro Sciences, Inc.

Margaret Whittaker, PhD, MPH, CBiol, FRSB, ERT, DABT, ToxServices LLC


This course was recorded in May 2019. Credentials and affiliations for speakers and presenters may have changed since the recording.


The videos in this course are available with English and Spanish subtitles. To access these, select the "Settings" (gear) icon within the video.

Content
  • Course Introduction
  • Section 1: Regulatory Landscape
  • 1.1 Opportunities for Bridging and Waiving Studies for Pesticide Registration 
  • Section 2: Acute Systemic Toxicity
  • 2.1 Introduction to Acute Systemic Toxicity and NAMs
  • 2.2 In Vitro Models and In Silico Dosimetry for Human Health Risk Assessment
  • 2.3 Alternative Approaches for Fish Acute Toxicity
  • Section 3: Computational Demonstrations
  • 3.1 Computational Tools for Predicting Acute Oral Toxicity
  • 3.2 A Large Multitask Neural Network for Chemical Properties
  • 3.3 The EPA CompTox Chemicals Dashboard
  • 3.4 High‐throughput Tools for PoD Estimation
  • 3.5 Using HT‐IVIVE and PBPK in PLETHEM to Establish a MoE for Risk Assessment
  • 3.6 Computational Models for Regulatory Toxicology
  • 3.7 SaferSkin™ ‐ Integrated Testing Strategy
  • 3.8 Acute 6‐pack: Testing Strategies for Pesticide Actives and Formulations
  • 3.9.1 Necessity Driven: Respiratory Assay Development for Regulatory Toxicology
  • 3.9.2 Necessity Driven: Respiratory Assay Development for Regulatory Toxicology
  • Section 4: In Vitro Approaches
  • 4.1 Regulatory Accepted In Vitro Methods for Ocular Irritation/Corrosion 
  • 4.2 NAMs for Assessing the Skin Sensitization Potential of Chemicals 
  • Section 5: Application of NAMs for Greener and Safer Chemistries
  • 5.1 Application of NAMs for Greener and Safer Chemistries
  • Course Survey, Evaluating Toxicological Information Using Modern Science
Completion rules
  • All units must be completed
Back