Computational Toxicology

Practical Applications of NAMs in Chemical Safety Assessment: Applying US EPA Tools & Approaches


Description

Welcome to the NURA course Practical Applications of NAMs in Chemical Safety Assessment: Applying US EPA Tools and Approaches in Practice.


This hands-on training course provides users with a working knowledge on how to effectively access and exploit the many different data streams available in the EPA’s CompTox Chemicals Dashboard to support different regulatory purposes. The training is targeted towards regulatory scientists, students, and researchers. The course includes an overview of the dashboard itself and its main capabilities, before providing more in-depth training through case studies for each data stream (e.g. interpretation of ToxCast high-throughput screening data, use of read-across, and generating QSAR predictions). A final case study showcases how to integrate all the different data streams together for chemical safety assessment purposes.


Speakers:

Moderator: Esther Haugabrooks, PhD, DABT, (formerly) Physicians Committee for Responsible Medicine

Antony J. Williams, PhD; Center for Computational Toxicology & Exposure, US EPA

Katie Paul Friedman, PhD; Center for Computational Toxicology & Exposure, US EPA

John Wambaugh, PhD; Center for Computational Toxicology & Exposure, US EPA

Kristin Isaacs, PhD; Center for Computational Toxicology & Exposure, US EPA

Nancy Baker, PhD; (formerly) Leidos contracting with US EPA

Grace Patlewicz, PhD; Center for Computational Toxicology & Exposure, US EPA


This course was recorded in October 2020. Credentials and affiliations for speakers and presenters may have changed since the recording.


The videos in this course are available with English and Spanish subtitles. To access these, select the "Settings" (gear) icon within the video.

Content
  • Introduction: EPA Tools
  • 1.1 Introduction to the US EPA CompTox Chemicals Dashboard
  • 1.2 CompTox Chemicals Dashboard & ToxCast/Tox21 Screening Program: User Tools
  • 1.3 High Throughput Toxicokinetic Modeling
  • 1.4 Data & Models from the ExpoCast Project for Informing Chemical Assessment
  • 1.5 Abstract Sifter: Text Mining for Efficient Literature Search & Retrieval
  • 1.6 Generalised Read-Across (GenRA): Data driven systematic RA approaches
  • Course Survey, US EPA Tools
Completion rules
  • All units must be completed
  • Leads to a certificate with a duration: Forever