Welcome to NURA's FDA Case Study #1: The Utilization of Human-on-a-Chip Systems for Regulatory Submissions for Neurological Conditions.

This webinar featured a presentation by Hesperos, Inc. founder and chief scientist, Dr. James "J" Hickman.  Dr. Hickman discussed Hesperos' research focusing on the establishment of functional in vitro systems to create organs and subsystems to model motor control, muscle function, myelination and cognitive function, as well as cardiac and liver subsystems.

Specific embodiments of this technology include the creation of a functional human neuromuscular junction (NMJ) system to understand Amyotrophic Lateral Sclerosis (ALS), Myasthenia Gravis (MG), Charcot-Marie-Tooth Disease (CMT), and a long-term potentiation (LTP) for Alzheimer’s Disease (AD) utilizing clinically relevant functional readouts.

The models have demonstrated variations of the disease phenotype compared to wild-type (WT) motoneurons for NMJ stability and functional dynamics and data from this system has been utilized for investigational new drug (IND) applications.

Speakers:

James "J" Hickman, PhD, Hesperos, Inc.

Eryn Slankster-Schmierer, PhD, Physicians Committee for Responsible Medicine, Moderator

This course was recorded in September 2024. Credentials and affiliations for speakers and presenters may have changed since the recording.

The videos in this course are available with English and Spanish subtitles. To access these, select the "Settings" (gear) icon within the video.